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In sum, as summarized in Figure 8, our data indicate that, in smoking-induced COPD/emphysema, miR-125a-5p via Sp1 regulation of SIRT1/HIF-1 is involved in the senescence of lung epithelial cells

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Mandel stayed for more than a month and had again a number of significant contacts, since at the time Cuba played a key role on the international stage as founder of the Latin-American Solidarity Organization (OLAS), a structure that brought together a large number of political organizations inclined to armed struggle