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2023;21(January):13 KEYWORDS TOPICS ABSTRACT Asthma is a prevalent chronic airway inflammatory disease involving multiple cells, and the prolonged course of the disease can cause airway remodeling, resulting in irreversible or partial irreversible airflow limitation and persistent airway hyperresponsiveness (AHR) in asthmatics

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The hand roller spirals the wrapper leaf around the binder and filler several times, and then finished it off by securing the end of the wrapper with a vegetable paste

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