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12 The rats in the smoking group were exposed to smoke in a homemade fumigation box (0.90.60.6 m)

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MR analyses using lifetime smoking as the exposure variable showed significant effects in the same direction, with a similar effect size (OR IVW = 1.72, 95% CI 1.292.28, P = 1.8 10 4 ) (Table 1, supplementary Figs 79)