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J Clin Med 7:282 Li H, Wu Q, Xu L, Li X, Duan J, Zhan J, Chen H (2015) Increased oxidative stress and disrupted small intestinal tight junctions in cigarette smoke-exposed rats

Ideally, an RCT would enroll cigarette smokers seeking to quit and randomly assign them to switch from smoking combustible tobacco cigarettes to either using e-cigarettes or a comparison condition