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First, we examine whetherliving with a parent who smokes when a child is aged 9 or 13 years (childhood and early adolescence) increases the risk of subsequent teenage substance use (cigarettes, e-cigarettes, alcohol and other drug use) at age 17/18 years, and, if yes, whether this risk differs if one or both parents smoke when the child is aged 9 or 13 years, and whether the risk increases when each parent is reported smoking at 9 and 13 years

Further research into the lncRNA-miRNA-mRNA interaction network found that let-7c-ADRB1-HLA-DQB1-AS1 interactions may play a key role in the pathogenesis in smoking COPD patients

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