On the other hand, interestingly, the ability of MAO inhibitors to ameliorate dopaminergic deficits underlies their clinical potential to treat depression, anxiety, and Parkinsons disease ( Self-medication hypothesis Combined, the above and other observations are consistent with the self-medication hypothesis, revisited from a neurobiological perspective, which asserts that the nicotine in tobacco may relieve or help manage specific psychiatric symptoms ( Growing evidence suggests that the cognitive enhancement effects of nicotine may also contribute to the difficulty of quitting smoking, especially in individuals with psychiatric disorders who suffer from emotional, cognition and behavioral symptoms
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Cotinine reduces depressive-like behavior, working memory deficits and synaptic loss associated with chronic stress in mice
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