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Beijing: Peoples Medical Publishing House (2012)
By comparing model 1 and model 2, the current study observed a weakening of statistical significance and effect sizes across 11 brain regions when BMI was added, suggesting a possible, but not definitively proven, mediating effect of BMI in the association between the increase in smoking pack years and reduced brain volumes
Subgroup analysis by study design showed that the pooled OR of cohort studies was unadjusted 1.18 (95% CI: 0.961.44, I 2 =77%, p=0.11) and adjusted 1.18 (0.96-1.44, I 2 =77%, p=0.11), while that of case-control studies was unadjusted 1.12 (95% CI: 1.031.21, I 2 =28%, p=0.005) and adjusted 1.10 (95% CI: 1.001.20, I 2 =34%, p=0.05)
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