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regulations list 7-hydroxymitragynine as a Schedule I controlled substance, but they do not appear to specifically address mitragynine or natural kratom leaf, per the Legislative Analysis and Public Policy Associations state law tracker, and California doesnt have an outright ban but has effectively blocked commercial sales through administrative action from its public health department
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Available data suggest that interactions vary based on multiple factors, including the class of antidepressant, dosage, frequency of cannabis use, individual metabolism, and genetic differences
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