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Insert it into the IQOS ILUMA device, making sure its securely positioned

Patterson had introduced the brand as chewing tobacco in 1871, inspired by the gold rush

This screening criterion using the cutoff value of 0.25 follows the Purposeful Selection of Covariates strategy, which aims to retain not only statistically significant variables but also potential confounders that may not demonstrate a strong association in univariable analysis but could become important in the multivariable model