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[38] The August warning letter to ITG marked the first time the FDA had used its authority under a 2009 tobacco-control law to take action against a company for making "additive-free" ("No Bull" ad campaign) claims on product packaging

[23] Individual Level Treatments vs Population-Level Policies: Many of the oral nicotine product manufacturers state that their products are intended for and marketed solely to adult populations who currently use combustible tobacco

Combined Effect of Alcohol and Tobacco in Causing Head and Neck Cancer When tobacco is smoked, it releases thousands of harmful chemicals that pass directly through the mouth, throat, and larynx, causing direct toxic damage to the head and neck tissues