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10.1046/j.1365-2362.2000.00739.x Yamamoto R, Kawamura T, Wakai K, Ichihara Y, Anno T, Mizuno Y, Yokoi M, Ohta T, Iguchi A, Ohno Y: Favorable life-style modification and attenuation of cardiovascular risk factors

The different meta-analyses found not very strong evidence that the combination of different types of NRT is associated with a significant increase in its efficacy.33,34 On the other hand, one study has demonstrated that the combination of bupropion and nicotine patches significantly increases the efficacy of the patches, but not that of bupropion used alone.33,34,61 There are no precise indications for the use of combined therapy

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