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Advise patients to stop taking CHANTIX at the first sign of rash with mucosal lesions or skin reaction and contact a healthcare provider immediately [see Warnings and Precautions (5.8), Adverse Reactions (6.2)]

Smoking during this period can seriously interfere with healing because it: Avoiding smoking during these critical first days gives your body the best chance for a smooth, complication-free recovery

The show uses this for the first time in the fourth episode in, starting Leela's reluctant running joke about "crossing paths" with Zapp Brannigan

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