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"Smokeless tobacco and Cancer." Lancet Oncol Jul;9(7):667-75

Nicotine, the primary addictive component of tobacco, acts on nicotinic acetylcholine receptors in the brain, leading to the release of dopamine and other neurotransmitters associated with pleasure and reward

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How long nicotine stays in your system depends on many factors such as age, weight, gender, frequency of use, and physical fitness