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PA can be further oxidized by xanthine oxidase (XO) to form 5-hydroxy-pyrazinoic acid (5-OH-PA), a metabolite thought to be more hepatotoxic than PA
This method of absorption can actually lead to a more prolonged nicotine buzz, which might explain why some folks swear by it
Peer review Peer review information Nature Communications thanks Saman warnakulasuriya, Peter Lee and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Despite lacking the smoke of cigarettes, chewing tobacco is packed with harmful chemicals that can wreak havoc on your teeth and overall well-being
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