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Ethics declarations Competing interests FN has received consulting fees from most pharmaceutical companies in the field of hypertension and diabetes, as well as Haypp group and the Environment and Public Health Institute of Sweden related to his previous trial on the acute effects on nicotine in snus

Brands targeted at youth are typically marketed as smoother and less harsh, and include flavors that may be more palatable such as mint, or strawberry

Once approved, the amendment is submitted to Health Canada in compliance with procedures for regulated trials