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Helen and colleagues, acknowledges that All substances in PMIs list of 58 constituents (PMI-58) were lower in IQOS emissions compared with mainstream smoke of reference cigarettes. That accurate statement is followed by the suggestion that PMI ignored that levels of 56 other constituents, which are not included in the PMI-58 list or FDAs list of [harmful and potentially harmful constituents], were higher in IQOS emissions. The authors criticize PMI for not undertaking non-targeted chemical analysis to identify these compounds