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The signings included pitcher Alex Fernandez and outfielder Moises Alou, as well as a controversial signing of Bonilla to a four-year contract worth $23.3 million

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However, the study, published in the Lancet Medical Journal on Wednesday, also argues that the war on tobacco is far from won, and policy makers need renewed and sustained efforts to tackle the epidemic. Although there has been a marked reduction in the number of smokers globally, there were still nearly one billion smokers in 2015, and half of all the 6.4 million deaths attributed to smoking in 2015 were concentrated in just four countries - China, India, Russia and the USA

Am J Physiol Regul Integr Comp Physiol