Moreover, latest findings still suggest CYP3A4s role is minor, highlighting CYP2C8, CYP1A2, and CYP2D6 as key enzymes in converting pioglitazone to M-IV (Muschler et al., 2009)
Ectopic pregnancy, when the baby grows outside the womb is another possibility
Kidney Int 2000
If the smoking status is already documented, it can be asked: I see from your notes that youre a smoker, are you still smoking? If they are recorded as ex-smokers, it is vital to re-check as approximately 70% of ex-smokers will eventually relapse within a few years, further questions that can be used are: According to your records you quit smoking, how are you getting on with that? When advising it is important to take the perspective of educating not judging or coercing, for example: Ok, I am not sure whether you are aware, but there are several negative consequences to you and your baby of smoking during pregnancy, and it is entirely your choice, but we know that the best way to stop is with extra support, which is available in the NHS
