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Orwell critiques this inconsistency, suggesting that the dangers of smoking are comparable to some illicit drugs, yet cigarettes have gained cultural legitimacy
However the protective effect observed in PEP may occur through nicotine, a major toxic component of tobacco (see section on Nicotine ), which activates the nicotinic anti-inflammatory pathway, and can reduce pancreatic inflammation (48, 73, 109, 113)
What public health strategies are needed to reduce smoking initiation
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