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A literature review by Tolins et al

In 1619 CE, the first Africans arrived in Jamestown via a Dutch ship and, although frequently referred to as slaves, seem at first to have been treated in the same way as indentured servants

Ldicke F, Ansari SM, Lama N, Blanc N, Bosilkovska M, Donelli A, et al: Effects of Switching to a Heat-Not-Burn Tobacco Product on Biologically Relevant Biomarkers to Assess a Candidate Modified Risk Tobacco Product: A Randomized Trial

For example, there is substantial evidence showing that propylene glycol, vitamin E acetate, and metals such as lead and arsenic are important components of some e-cigarettes [22,23,24]