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According to reporting from The Verge, Its difficult to quantify the effect that plain packaging has on consumer behavior, though studies have shown that it likely acts as a deterrent: A series of papers published in the journal Addiction found that the neutral packs led to a decline in smoking at outdoor restaurants, cafes, and bars in Australia, while others have shown that they make cigarettes seem less appealing to adolescents

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2 In addition, the MAPK-signaling pathway is closely associated with smoking-induced abnormal differentiation of bronchial epithelial cells and increased secretion of Muc5AC