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Although we had only summary data (hence limited ability to show trends reliably), we saw some suggestion of a positive trend between the size of the relative risk for smoking one cigarette per day and the last calendar year of follow-up for each study: Spearmans correlation 0.51 (P=0.008) for men and 0.21 (P=0.42) for women when we used studies of coronary heart disease, and 0.23 (P=0.39) and 0.56 (P=0.11) among men and women for studies of stroke