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The self-medication hypothesis suggests that schizophrenia patients smoke, in part, to alleviate negative symptoms, dysphoric mood, and neurocognitive impairments by ameliorating a dysfunctional dopamine system.10 The addiction vulnerability hypothesis suggests that genetic and neurobiological factors associated with schizophrenia (ie, alterations in nicotinic acetylcholine receptors [nAChRs] and central dopamine systems) may predispose schizophrenia patients to nicotine addiction.11 Examining the effects of tobacco smoking on neurocognition in schizophrenia is crucial because it may help clarify the rationale for high consumption of tobacco products and inform treatment interventions

The absence of artificial enhancement means the taste profile remains consistent throughout the cigarette

Among women (five studies),2838404755 the relative risks for stroke were 1.46 and 2.42 for one and 20 cigarettes per day, and one cigarette per day had 36% of the excess relative risk for 20 cigarettes per day

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