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Using a standard mouthpiece device nasally may increase the risk of discomfort or irritation compared to a purpose-designed nasal adapter

Down-regulated peroxisome proliferator-activated receptor (PPAR) in lung epithelial cells promotes a PPAR agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)

...'When weighty matters are in debate, Mithrandir, I wonder a little that you should play with your toys of fire and smoke, while others are in earnest speech.' +(Saruman's perception at the time was that Gandalf was idly practicing magic, since fire magic was Gandalf's chief area of study.) +It was at this time Saruman secretly took up the practice of smoking pipe-weed - prompted by his jealousy of Gandalf

Evidence review of e- cigarettes and heated tobacco products 2018