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The 2021 report estimates that over 9.7 billion cigarette butts, e-cigarettes, vape pens and cartridges are littered in the United States each year, and more than four billion of these are in our waterways

This makes it impossible to know whether e-cigarette use caused prediabetes or diabetes

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Other studies have also reported that vanillin, ethyl vanillin, and ethyl maltol are often used in EC products 28,29 , further supporting the idea that refill fluid manufacturers use a relatively small subset of the flavor chemicals available