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Third, many biomarker analyses lacked representation from dual users or had underrepresentation of smokers or non-smokers as reference groups, which may have reduced comparative power (especially cytokine data)

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This long-term continuity highlights the brands ability to adapt to changing national conditions

If FDA determines that the tobacco product standard is appropriate for the protection of public health based on an evaluation of public comments, a report from TPSAC (if the standard was referred to them), and other evidence, the agency must promulgate a final regulation to establish the standard