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They then observed that when the cells treated with nicotine were subsequently exposed to environmental causes of mutation, such as UV rays, the nicotine-exposed cells had between two and four times more spontaneous mutations, suggesting that the nicotine predisposed cells to mutation from other sources

We included empirical quantitative and qualitative studies, as well as high-quality reviews and policy reports, that reported outcomes such as ever use, current use, daily use, cessation-related use, or dual use by at least one socioeconomic indicator

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It could be a dirty air filter or condensation which has created mold in the unit