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For instance, in his ground-breaking paper on Brownian movement, explaining the patterns of movement of tiny particles in gases or liquids, the dance of pipe smoke was used as the example cementing the existence of atoms and molecules

While some mutational processes are exogenous, resulting from exposure to factors such as tobacco smoke or UV radiation, others are endogenous, arising from mutagenic processes related to aging or inflammation, such as APOBEC cytosine deaminase mediated DNA damage [35, 36]

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