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This effect was further accompanied by reducing T-bet and augmentation of GATA-3 and lower NF-B-mediated transcription of I-B and IL-2 [140]

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In the short term, youll have: Bad breath Stains on your teeth Mouth sores Over a longer period of time using smokeless tobacco will cause: Your body to become dependent on it Your lips to crack, and both your lips and gums to bleed Your gums to recede (pull back from the teeth), possibly leading to your teeth falling out Your heart rate and blood pressure to rise and your heartbeat to become irregular