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Int J Environ Res Public Health 10:38863907 Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Murata M (2017) Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis

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[17] While the FTC has always recognized that the smoking machine cannot accurately replicate human smoking and that no two human smokers smoke in the same way, the FTC did not initially recognize the tobacco industry's ability to design cigarettes that yielded low levels of tar and nicotine when machine-smoked, but yielded much higher levels when smoked by a human being

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