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In lung cancer, particularly non-small cell lung cancer (NSCLC), oncogenic alterations such as mutations in KRAS , EGFR , BRAF , and ALK rearrangements activate key signaling cascades, most notably the RASRAFMEKERK and PI3K-AKTmTOR pathways

The key is to use 3-4 second puffs (neither too short nor too long)

Check out the recap for this episode here , and follow the whole discussion here