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Certain HLA-DRB1 alleles (DRB1*0401, DRB1*0404, DRB1*0405, DRB1*0408, DRB1*0101, DRB1*102, DRB1*1001 and DRB1*1402), encoding the so-called shared epitope (SE) at amino acid positions 70 to 74 in the third hypervariable region of the DRB1 molecule, are associated with a higher susceptibility for RA [26]