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In a large study among 7130 participants of the Population Assessment of Tobacco and Health (PATH) Study, there was no difference in the biomarker concentration of inflammatory (high-sensitivity C-reactive protein, interleukin-6, fibrinogen, soluble intercellular adhesion molecule) and oxidative stress (urinary 8-isoprostane) between participants who used e-cigarettes and non-users 34

Other combinations of dysfunctions found were: olfactory, gustatory and salivary dysfunction (9.0%), olfactory, gustatory, salivary and trigeminal dysfunction (5.0%), olfactory and salivary dysfunction (4.0%), olfactory, gustatory and trigeminal dysfunction (4.0%), and olfactory and trigeminal dysfunction (2.0%), Fig