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[193] [194] Until the mid-20th century, the majority of the adult population in many Western nations were smokers and the claims of anti-smoking activists were met with much skepticism, if not outright contempt

The authors note an analysis of the effects of one such law adopted in Needham, MA, revealed a 47 percent reduction in the smoking rate among high school students, along with a reported decline in area retail tobacco purchases

The fMRI findings suggest that guanfacine may help improve control by increasing activation of specific control-related regions (anterior cingulate) and the more efficient processing of brain regions involved in executive functioning (dorsolateral prefrontal cortex) and attentional processing (parietal cortex)

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