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E-cigarette-makers are tackling the image problem head-on, with press releases talking about how Robert Pattinson, Leonardo DiCaprio, Ashton Kutcher, Katherine Heigl and Uma Thurman and other celebrities are turning to e-cigs

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As has been found for alcohol retailing, effective use of signage on and around stores can effectively bypass advertising restrictions to reach vulnerable population groups 35

Cigarette smoke inhibits ciliary activity of the bronchial epithelium and phagocytic activity of macrophages in the alveoli, resulting in decreased clearance of foreign material and bacteria from the lung, which leads to increased infection and tissue destruction