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The unique subset of EGFR mutation-lacking LCNS patients in Caucasian populations coincides with a subset of LCNS tumors that have been identified to have lower tumor mutational burden (TMB) and lack somatic copy number alterations (SCNAs), structural variants, and whole genome doubling as reported by Zhang et al., termed the piano subtype

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The announcement led to amendments to the Health Promotion Act, but heavy lobbying by the tobacco industry and opposition from within the government resulted in a weakened version of tobacco regulations being implemented