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(A) Patients given a 4-mg dose of nicotine with tablets containing 10 mg or 30 mg of methoxsalen (M10 and M30, respectively) showed higher mean blood nicotine levels and a dramatically reduced urge to smoke compared with patients receiving nicotine and a placebo (P) or 3.5 mg of methoxsalen (M3.5) (B) Similarly, over a 3-h time span, patients receiving the higher doses of the CYP2A6 inhibitor showed an improved ability to maintain their blood nicotine levels

Compliance checks will also be increasing from at least one to at least two per year, while fines for selling to a person prohibited from purchasing tobacco will go up significantly