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however, no correlation was found between the changes in protamine expression and sperm parameters [97, 105] and can be explained by the fact that nicotine causes protamine dysfunction due to mutations and polymorphisms in MARs that may change the ratio and level of protamine [81]

While there may be concerns regarding setup costs, complexity, and the potential for customers to "game" the system, you can mitigate these challenges by using a robust point of sale (POS) system to track and manage your loyalty program (well go into more detail on how below)