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We break exact linear dependency between the three explanatory variables (i.e., cohort = period age) and deal with under-identification by grouping birth cohorts into frequently used 5-year intervals, and, after confirmation of a curvilinear relationship, treat smoking as a quadratic function of age 30

Phylogenetic analysis of the concatenated dataset recovers major clades consistent with transcriptome-based studies and reveals several lineages that may require taxonomic revision

The Centers for Disease Control and Prevention (CDC) states that 2.06 million US middle and high school students have used e-cigarettes in the last 30 days. That includes 11.3% of high school students and 2.8% of middle school students