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Abbreviations COPD: Chronic obstructive pulmonary disease C-EBP: CCAAT/enhancer-binding protein EMT: Epithelialmesenchymal transition CSE: Cigarette smoke extract IL-17R: IL-17 receptor HE: Hematoxylin and eosin PAS: Periodic acidSchiff References Mouronte-Roibs C, Leiro-Fernndez V, Fernndez-Villar A, Botana-Rial M, Ramos-Hernndez C, Ruano-Ravina A

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Besides, more than half of the healthcare providers, and the general population, agreed that using E-cig is a public health concern (Dwedar et al ., August Reference Dwedar, Ruby and Mostafa2019)