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The drug release kinetics can be explained by the Higuchi matrix model, which states that the drug release is controlled by the diffusion of a small liquid into a polymer matrix according to Fickian diffusion

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While vaping is considered 95% less harmful than smoking, the flavourings do contribute to the volatile compounds formed in the vaping process, suggesting that freebase nicotine liquids with less flavouring could well be that little bit safer than nic salt liquids

6 Smoking cannabis can also increase carboxyhemoglobin levels, which may compromise tissue oxygenation