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Dose-dependent reductions in forced expiratory volume (FEV1) and airflow limitation make COPD a leading cause of morbidity and mortality in smokers

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Therefore, we separated our analysis of HRV and morphology parameters into 4 discrete phasesBaseline (BL), mid-exposure (Expo, all min of puff sessions), early after exposure (Post-, 49 min after each puff session), and late after exposure (Late Post-, 928 min after final puff session)