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The spate of harm and threat to human life as a result of smoking is becoming worrisome

These so-called second-line tobacco treatment medications, such as clonidine and nortriptyline, are used less often and do not have an official FDA indication for tobacco cessation

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In a randomized crossover trial comparing healthy subjects who smoked tobacco (maximum of 10 cigarettes per month), the acute use of nicotine-containing e-cigarettes significantly increased levels of circulating endothelial progenitor cells (flow cytometry) to the same magnitude as after smoking a traditional cigarette (41)