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In NSCLC and intrahepatic cholangiocarcinoma of the liver cancer, the mitochondrial urea cycle enzyme CPS1 was downregulated either directly (Figure 5, I and K) or via reduced expression of NAGS , the enzyme that produces its essential cofactor N -acetylglutamate, respectively (Figure 5, J and L, and Supplemental Figure 4B)

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From Hawaii, clearly an affordable, pro-worker paradise, to bleak Montana, B can range from 1 minute and 44 seconds to 5 minutes and 2 seconds all very short times in the scheme of things