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As referenced in a previous article examining the nicotine content of disposable vapes compared to traditional cigarettes, research shows that on average, only around 1.1-1.8 mg of nicotine actually enters the bloodstream when smoking a typical tobacco cigarette

The biochemical processes also lead to immunomodulation and dysregulated repair processes, so the malfunction of macrophages renders individuals more susceptible to infections

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Carbon monoxide in cigarette smoke makes this worse by binding to hemoglobin and further reducing oxygen transport