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Morover, the levels of NNK and NNN in sun-dried tobacco were several fold higher than in green tobacco.[] In vitro nitrosation of BQT at pH 7.4 existing in oral cavity did not increase NNN levels significantly, while a significant increase in NNN levels occurred at pH 2.1 similar to that in the stomach.[] High concentration of NAT at both pH values indicated that additional N-nitroso compounds may be produced in the oral cavity and stomach of tobacco chewers

The pilot test focused especially on items developed specifically for the Focus study by the research team

Most Habitual Smokers Begin Before Their 21st Birthday The Institute of Medicine of the National Academies states that most adult smokers began the habit before age 21