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KPMG estimates that more than 35 billion counterfeit and contraband cigarettes were consumed in the EU in 2022, amounting to 8.2 percent of total cigarette consumptionand a loss of 11.3 billion ($12.2 billion) in tax revenues

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Collectively, these nicotine-mediated factors result in altered blood homeostasis that consequentially promotes platelet-dependent thrombosis, increases the risk of ischemic stroke, and exacerbates secondary brain injury (Wannamethee et al., 2005