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While these studies using newer radioligands with increased affinity for TSPO report differences in binding between PLWH and controls, earlier studies of this type [22, 23] using an older, first-generation TSPO radioligand with less specific binding did not

This apparatus consisted of a polypropylene square arena (40 cm long 32 cm high), whose floor was subdivided into 16 squares and whose walls prevented the animals from exiting