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In many of the behavioral and cognitive tests including swimming speeds and migrating through a maze wild-type mice were more affected than human tau mice after both groups were exposed to second-hand smoke

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In addition, crosstalk between TGF-/Smad signaling and other pathways, including PI3K/Akt/mTOR and Wnt/-catenin, may further amplify senescence-associated phenotypes, suggesting that fucosylation-dependent modulation of TGF- receptor activity could have broader network-level effects

It is thought that myrcene may increase the permeability of the bloodbrain barrier [2] , which could in turn affect the speed at which cannabinoids are able to cross it, potentially amplifying their effects