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The constriction of blood vessels and potential disruption of hormonal balance due to nicotine are primary factors that might lead to hair loss in individuals who use smokeless tobacco

[84] To support its assertion that DARZALEX FASPRO significantly improves hemCR rate, the applicant stated that the trial results showed that patients treated with DARZALEX FASPRO demonstrated a statistically significant increase in hemCR compared to control (53.3% versus 18.1%